trans-4-Hydroxycrotonic acid (T-HCA), also known as γ-hydroxycrotonic acid (GHC), is an agent used in scientific research to study the GHB receptor.[1] It is an analogueof γ-hydroxybutyric acid (GHB), as well as an active metabolite of GHB.[2][3][4] Similarly to GHB, T-HCA has been found to be endogenous to the rat central nervous system, and as a metabolite of GHB, is almost certain to be endogenous to humans as well.[3][5] T-HCA binds to the high-affinity GHB receptor with 4-fold greater affinity than GHB itself,[6] where it acts as an agonist,[1][7] but does not bind to the low-affinity GHB binding site, the GABAB receptor.[3][8] Because of this, T-HCA does not produce sedation, and instead causes convulsions, which are thought to be caused by GHB receptor activation-evoked increases in extracellular glutamate concentrations, with one notable area where this occurs being the hippocampus.[8]

CBG oil (also called cannabigerol oil, CBG rich cannabis extract, cannabis oil, cannabis extract, hemp extract, hemp oil, hash oil, or concentrated cannabis extracts) is an oleoresinextracted from Cannabis plants which contains cannabigerol (CBG). CBG-rich cannabis extracts are botanical extracts where the raw material used in the extraction is Cannabiscontaining high amounts of CBG and low amounts of tetrahydrocannabinol (THC). CBG oil is a new word for a product very similar to hash oil that became popular in the 1970s.[1]

CBG oil is similar to CBD oil, with the only difference being that the dominant ingredient is CBG instead of cannabidiol (CBD). The cannabigerol content of CBG oil varies tremendously, since the manufacturers use a varying assortment of Cannabis plants and preparation techniques. Some manufacture CBG oil by mixing the CBG-rich Cannabis extract with other liquids such as hemp seed oil, olive oil, or MCT oil

In January 2015, researchers studying CBG in mice discovered neuroprotective effects with Huntington’s disease and have shown promising results in slowing down colon cancer. CBG marijuana strains will hopefully be used therapeutically as an antidepressant, and as a functioning painkiller. Researchers suggest that CBG marijuana strains will also be beneficial for the treatment of psoriasis, glaucoma, multiple sclerosis and skin diseases.