THCV + a-terpineol
THCV, or tetrahydrocannabivarin, is a compound in cannabis that offers a unique array of effects and medical benefits that sets it apart from other cannabinoids like THC and CBD. Whether you’re a medical marijuana patient looking for a particular type of relief or a casual consumer chasing a specific effect, we’d like to introduce you to this fascinating compound that’s sure to make major waves in the cannabis world as we discover and utilize its full potential.
One reported effect of THCV which may be very important to modern society is appetite suppressant ability. In Australia3 and the USA4, approximately two-thirds of people are overweight or obese. The underlying mechanism of this is its ability to suppress CB1 receptors, with a dose of 3mg per kilogram of body weight found to be the correct dose in this study5.
However, a cannabis extract high in THCV failed to produce this effect, but this was most likely due to the presence of THC. Adding CBD then prevented this effect of THC, which means that hemp extracts fortified with THCV may be the best formulation for weight loss. This is not a substitute for healthy diet and exercise, and human clinical trials are needed, but use of an extract such as this could help to break the habits surrounding over-eating and aid introduction of healthier behaviour.
a-terpineol is a monoterpene, part of the terpinene subfamily of terpenes. This family of four isomers is known for being anti-oxidant, immune-modulating and anti-biologically (anti-tumor, antibacterial, antifungal). It has also been used, for hundreds of years, in the treatment on insomnia. a-terpineol is found in oregano, marjoram, cumin, lilac, some citrus rind and conifers.
Terpinolene is a common component of sage and rosemary and is found in the oil derived from Monterey cypress. Its largest use in the United States is in soaps and perfumes. It is also a great insect repellent. Terpinolene is known to have a piney aroma with slight herbal and floral nuances. It tends to have a sweet flavor reminiscent of citrus fruits like oranges and lemons.
Terpinolene has been found to be a central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. Further, terpinolene was found to markedly reduce the protein expression of AKT1 in K562 cells and inhibited cell proliferation involved in a variety of human cancers.