CBCA + beta-sitosterol

Beta-Sitosterol June 2005 By Stephen B. Strum, MD, FACP, and William Faloon Whether from benign enlargement or cancer, prostate disorders wreak havoc on the majority of aging men. Doctors have identified nutrients and drugs that alleviate symptoms of benign enlargement and reduce prostate cancer risk. An overlooked plant extract called beta-sitosterol may be of particular benefit. Scientific studies indicate that beta-sitosterol consistently improves urinary symptoms related to prostate enlargement.beta-sitosterol improved urinary symptom scores and urinary flow rates, and significantly reduced the volume of residual urine in the bladder.6,7 Table 1 summarizes some of the randomized studies of beta-sitosterol in the treatment of BPH. Table 1. Summary of Key Randomized Studies of Beta-Sitosterol in BPH Patients. Effects of beta-sitosterol on the International Prostate Symptom Score (IPSS), maximum urinary flow rate (Qmax), and post-void residual volume (PVR) are remarkably consistent. The study by Wilt and colleagues7 examined four different randomized studies. The magnitude of reduction in prostate symptoms and improvement in urinary flow rates is a strong incentive for the use of beta-sitosterol, either alone or in combination with standard pharmacologic interventions such as alpha-adrenergic blockers (Cardura®, Hytrin®, Uroxatral®, Flomax®) or 5-alpha reductase inhibitors (Proscar®, Avodart®). Beta-Sitosterol and Prostate Cancer A study using the prostate cancer cell line LNCaP (an androgen-dependent tumor) showed that beta-sitosterol decreased cancer cell growth by 24% and induced apoptosis (programmed cell death) fourfold. These findings were correlated with a 50% increase in ceramide production.8 Research suggests that ceramide, an important component of the cell membrane, induces apopotosis.9 Growth of the human prostate cancer PC-3 cell line (androgen-independent)