THC D8 + apigenin
Delta-8-THC is one of the four major cannabinoids present in dried. In total, some experts estimate that there are 113 cannabinoids. While delta-8-THC may be one of the most common, it still often makes up far less than 1 percent in dried flower. In fact, there’s often only about 0.01 percent delta-8-THC in dried cannabis flower.
Apart from THC, the other common cannabinoids include cannabidiol (CBD) and cannabinol (CBN). Like “regular” THC, delta-8 is psychoactive. Though, it is considered slightly less psychoactive than it’s more famous relative.
In terms of potency, research suggests that the psychoactive strength of delta-8 can be compared to THC in a 2:3 ratio. This means that it is more potent than tetrahydrocannabivarin (THCV), which is thought to be responsible for the zippy, energetic high present in some strains. THCV only has a potency of about 25 percent of THC.
Delta-8-THC connects with the same primary landing sites as the traditional THC. This landing site is known as cannabinoid receptor 1 (CB1) and facilitates a wide variety of bodily functions, including mood, memory, pain, movement, sleep, and more.
The cannabinoid has also been found to connect with the cannabinoid receptor 2 (CB2), which lends a hand in immune system communication.
Rodent studies show that delta-8 also boosts a particular chemical in the brain that plays a role in learning and memory. That chemical is the neurotransmitter acetylcholine. Deficiencies in acetylcholine are thought to contribute to Alzheimer’s disease and other memory and cognitive problems. In fact, according to the U.S. National Cancer Institute, early research on delta-8-THC has shown that the chemical may have several beneficial effects. These include:
Researchers have also looked into the benefits of non-psychoactive derivatives of this molecule. This shows that the compound may be useful for the potential creation of new pharmaceutical drugs.
Some delta-8-THC derivatives, researchers speculate, may be helpful in conditions asthma, systemic anaphylaxis, and septic shock. Others are being studied for interstitial cystitis, as well as for inflammation and pain-relieving effects. Unlike delta-8-THC, many derivatives are thought to be non-psychoactive.
Apigenin readily crosses the blood-brain barrier and has not demonstrated toxicity at high doses. It could thus prevent amyloid beta deposition and tau phosphorylation due to neuroinflammation, which can lead to Alzheimer's disease.
Through effects on cell signaling, inflammation, cell cycle, and protease production, apigenin has demonstrated effectiveness against a wide range of cancer types, while not showing toxicity to normal cells. Apigenin is found in many fruits and vegetables, but parsley, celery, celeriac, and chamomile tea are the most common sources. Apigenin is particularly abundant in the flowers of chamomile plants, constituting 68% of total flavonoids